ZO-1抗体，胞质紧密粘连蛋白1/闭锁小带蛋白1抗体

产品名称：Rabbit Anti-ZO-1  antibody

Rabbit Anti-ZO-1 

别名：ZO1_HUMAN; Tight junction protein ZO-1; TJP1; ZO1; Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1; ZO1 tight junction protein; 

来源：Rabbit

克隆类型：Polyclonal

浓度：1mg/ml

亚型：IgG

应用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,Flow-Cyt=1μg/Test

反应: Human (predicted: Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog,GuineaPig,Goat)

理论分子量：191kDa

免疫原：KLH conjugated synthetic peptide derived from human ZO-1

保存：-20℃
保质期：1年

产品名称：Anti-ZO-1 antibody

Mouse Anti-ZO-1 

别名：ZO1_HUMAN; Tight junction protein ZO-1; TJP1; ZO1; Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1; ZO1 tight junction protein; 

来源：Mouse

克隆类型：Monoclonal

浓度：1mg/ml

亚型：IgG

应用： WB=1:1000-1:2000,Elisa=1:1000-1:2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,Flow-Cyt=1μg/Test

反应: Human

理论分子量：191kDa

免疫原：KLH conjugated synthetic peptide derived from human ZO-1

保存：-20℃
保质期：1年

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. 

Recombinant human ZO-1   

ZO1_HUMAN; Tight junction protein ZO-1; TJP1; ZO1; Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1; ZO1 tight junction protein; 

浓度：1mg/ ml

来源：Recombinant Human

纯度：≥95% SDS-PAGE

表达系统：Escherichia coli

标签：His tag  

蛋白长度：Full length protein

内毒素水平：<1.000 Eu/µg

纯化方法：HPLC

应用：SDS-PAGE，Western blot，ELISA

Biological activity,immunology research

保存：-20℃

保质期：1年

The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions.The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.